Clomiphene Citrate or Letrozole with IUI

Clomiphene Citrate or Letrozole with Intrauterine Insemination

Clomiphene Citrate or Letrozole  may be used to correct ovulation abnormalities in patients who do not ovulate well.They may also  be used to increase the number of eggs released by the ovaries in patients who are already ovulating normally. When more eggs are ovulated and more sperm reach the fallopian tubes, the pregnancy rate per cycle increases.  The average success rate for each cycle of Clomiphene Citrate or Letrozole with intrauterine insemination is 13% and is associated with a 5% to 8% incidence of multiple births. This treatment is commonly used as first line treatment for unexplained infertility and can also be effective for mild male factor infertility.

Clomiphene Citrate or Letrozole combined with Intrauterine Insemination (IUI) improves the pregnancy rate compared with Clomiphene Citrate or Letrozole and natural intercourse. Clomiphene Citrate may cause the cervical mucous of some women to thicken thus hindering passage of sperm through the mucous. The addition of intrauterine insemination overcomes this negative effect of Clomiphene Citrate.

Informed Consent

Informed consent is needed so that patients understand the risks and benefits involved in treatment with intrauterine insemination. It is therefore required that you have received, signed and witnessed important information regarding the use of reproductive material (sperm, eggs or embryos) as outlined in the “Assisted Human Reproduction Regulations on Consent“.